IB Biology HL Topic 4 — Genetics & Inheritance Paper 1 & 2 Core idea ~9 min read

Inheritance: Key Terms

Genetics questions are mostly short. That means the marker is checking one thing: did you use the right word? Get these terms straight and half the topic looks after itself.

📚 What you need to know

Gene, locus, allele

Picture one chromosome as a long shelf. Each gene has its own numbered spot on that shelf — its locus. Because chromosomes come in homologous pairs, you have two shelves side by side, and the same gene sits at the same spot on both.

The two copies do not have to be identical. Alleles differ by a small number of bases, sometimes just one. That tiny difference can change the protein enough to change the phenotype.

Same gene, same locus, two chances to differ A A B b d d locus 1 locus 2 locus 3 homozygous AA heterozygous Bb homozygous dd mother father one individual can be homozygous at one locus and heterozygous at another
Homozygous and heterozygous describe one locus at a time, not the whole organism. The same person is both, at different genes.
If a question says “state the genotype”, give the letters (Bb). If it says “state the phenotype”, describe what you would see (black fur). Answering the wrong one is a guaranteed zero even when your genetics is perfect.

What decides the phenotype

Three answers, and IB expects you to know all three.

Worth memorising phenotype = genotype + environment

Dominant and recessive

A dominant allele needs only one copy to show. A recessive allele needs two, because a single dominant allele will mask it.

So a recessive phenotype tells you the genotype straight away — it must be homozygous recessive. A dominant phenotype leaves you with two possibilities, homozygous dominant or heterozygous, and you often need more information to decide which.

Useful shortcut. Whenever you meet a genetics puzzle, fill in the recessive individuals first. They are the only ones whose genotype you can be certain about from the phenotype alone. Everything else follows from there.

Codominance and incomplete dominance

Sometimes neither allele hides the other, and you get more than two phenotypes.

Codominance: both alleles are fully expressed, side by side. A chicken with one white-feather allele and one black-feather allele grows white feathers and black feathers — it looks speckled, not grey. Human ABO blood groups work the same way: someone with IA and IB makes both antigen A and antigen B.

Incomplete dominance: each allele is only partly expressed and the phenotypes blend. A red-flowered plant crossed with a white-flowered one gives pink flowers — not red patches on white.

Both alleles show — but in two different ways CODOMINANCE both alleles fully expressed CRCR CWCW CRCW red white red and white INCOMPLETE DOMINANCE each allele only partly expressed CRCR CWCW CRCW red white pink Same genotypes. The difference is whether the two colours mix. both give a 1 : 2 : 1 phenotype ratio, because every genotype looks different
The test question to ask yourself: can you still see both original phenotypes in the heterozygote? Yes = codominance. No, it is something new in between = incomplete dominance.
The ratio changes too. With normal dominance a heterozygous cross gives 3 : 1, because BB and Bb look the same. With codominance or incomplete dominance the same cross gives 1 : 2 : 1, because all three genotypes look different. Spotting a 1 : 2 : 1 phenotype ratio in data is a strong clue.

Worked examples

WORKED EXAMPLE 1

In a plant, red and white flower colour show incomplete dominance. Two pink plants are crossed. Predict the phenotype ratio in the offspring.

Step 1: work out the pink genotype Pink is the blend, so pink must be heterozygous: CRCW Step 2: gametes Each parent makes CR or CW Step 3: combine 1 CRCR : 2 CRCW : 1 CWCW Step 4: convert to phenotypes Every genotype looks different here 1 red : 2 pink : 1 white Not 3 : 1 — that only happens when the heterozygote is hidden behind a dominant allele.
WORKED EXAMPLE 2

Two black rabbits produce a litter containing one white rabbit. Deduce the genotypes of both parents and explain your reasoning.

Step 1: start with the recessive individual White appeared from two black parents, so white must be recessive: white = bb Step 2: trace the alleles back The white rabbit got one b from each parent Step 3: fit that to black parents Each parent must carry b, but each also shows black, so each carries B Both parents are Bb (heterozygous) “Deduce” wants the reasoning as well as the answer — say where each allele came from.

💡 Exam tip

⚠ Common mix-up

Up next: Inheriting Alleles — phenotypic plasticity, recessive genetic conditions and blood groups with three alleles instead of two.

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